Journal article
Identification of Highly-Protective combinations of plasmodium vivax recombinant proteins for vaccine development
CT França, MT White, WQ He, JB Hostetler, J Brewster, G Frato, I Malhotra, J Gruszczyk, C Huon, E Lin, B Kiniboro, A Yadava, P Siba, MR Galinski, J Healer, C Chitnis, AF Cowman, E Takashima, T Tsuboi, WH Tham Show all
Elife | eLIFE SCIENCES PUBL LTD | Published : 2017
DOI: 10.7554/eLife.28673
Abstract
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p90%), EBP, DBPII, RBP1a, Cy..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
University of Melbourne Melbourne International Postgraduate Scholarship Camila Tenorio Franca Wen-Qiang He National Health and Medical Research Council 1092789 Alan F Cowman National Health and Medical Research Council Program Grant 1092789 Ivo Mueller Alan F Cowman Japan Society for the Promotion of Science JP26253026 Takafumi Tsuboi Japan Society for the Promotion of Science JP15H05276 Takafumi Tsuboi Japan Society for the Promotion of Science JP16K15266 Takafumi Tsuboi Australian Research Council Australian Research Council Future Fellowship Wai-Hong Tham National Institute of Allergy and Infectious Diseases Intramural Research Program Rick M Fairhurst National Institutes of Health A1063135 Rick M Fairhurst Wellcome 098051 Julian C Rayner Medical Research Council MR/J002283/1 Julian C Rayner Medical Research Council MR/L012170/1 Julian C Rayner National Institutes of Health U19A1089686 Ivo Mueller National Health and Medical Research Council 1021544 Ivo Mueller Malaria Eradication Scientific Alliance Ivo Mueller National Health and Medical Independent Research Research Council Institute Infrastructure Support Scheme Ivo Mueller National Health and Medical Research Council Senior Research Fellowship 1043345 Ivo Mueller